Retrospective and ongoing researches on Leishmania antimony resistance in Algeria
نویسندگان
چکیده
N. Eddaikra, K. Aït-Oudhia, B. Oury, Z. Harrat and D. Sereno Service d’eco-épidémiologie Parasitaire et Génétique des Populations Parasitologie, Institut Pasteur d'Algérie, Dely Ibrahim, Alger, Algeria. Ecole Nationale Supérieure Vétérinaire d’Alger, BP 161. Hassan Badi El-Harrach. Alger. Algeria. MIVEGEC (UM1-CNRS 5290-IRD 224) Institut de Recherche pour le Développement (IRD), BP 64501, 34394 Montpellier Cedex 5, France. *Both authors equally contribute to the work. Corresponding author
منابع مشابه
Reduced Antimony Accumulation in ARM 58 - Overexpressing 1 Leishmania infantum 2 Running title : ARM 58 antimony resistance marker
17 Antimony-based drugs are still the mainstay of chemotherapy against Leishmania infections in 18 many endemic countries. Efficacy of antimonials has been compromised by increasing numbers of 19 resistant infections, the basis of which is not fully understood and likely involves multiple factors. 20 By using a functional cloning strategy he have recently identified a novel antimony resistance ...
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Antimonials remain the first line drug against the protozoan parasite Leishmania but their efficacy is threatened by resistance. We carried out a RNA expression profiling analysis comparing an antimony-sensitive and -resistant (Sb2000.1) strain of Leishmania infantum using whole-genome 70-mer oligonucleotide microarrays. Several genes were differentially expressed between the two strains, sever...
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Protozoa of the Leishmania genus cause a variety of disease forms that rank at the top of the list of neglected tropical diseases. Anti-leishmanial drugs based on pentavalent antimony have been the mainstay of therapy for over 60 years and resistance against them is increasingly encountered in the field. The biochemical basis for this is poorly understood and likely diverse. No stringent correl...
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BACKGROUND Antimony resistance complicates the treatment of infections caused by the parasite Leishmania. METHODOLOGY/PRINCIPAL FINDINGS Using next generation sequencing, we sequenced the genome of four independent Leishmania guyanensis antimony-resistant (SbR) mutants and found different chromosomal alterations including aneuploidy, intrachromosomal gene amplification and gene deletion. A se...
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Leishmania drug resistance and particularly antimony resistance still continues to emerge in different part of the world. Because visceral and cutaneous leishmaniasis are transmitted in foci with zoonotic or anthroponotic life-cycles, the link between chemotherapeutic resistance and the selection for drug resistance, through drug consumption, cannot be as obvious for all forms of leishmaniasis....
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